The enclosed dataset includes conventional and surface enhanced Raman spectra (CR and SERS) for cocaine hydrochloride (CAS number 53-21-4), benzoyl ecgonine (CAS number 519-09-5) and paracetamol (CAS 103-90-2) solutions prepared in methanol:water (50:50) and synthetic oral fluid (SAE0149). Spectra of substances’ solutions were acquired using the Agilent Resolve handheld Raman spectrometer equipped with 830 nm laser wavelength. In CR mode, spectra were collected from each solution by measuring them through 2 mL glass vials using the vial holder. For SERS mode, both silver (in citrate buffer 10 nm diameter) and gold colloidal nanoparticles (in citrate buffer 20 nm and 40 nm diameter) were used alongside three aggregating agents being: lithium chloride, magnesium sulfate, potassium bromide and sodium chloride. The drug-colloid-aggregating agent solutions were measured also through 2 mL glass vial using the vial holder. In CR and SERS, spectra were collected in reflection mode over the wavenumber range of 350-2000 cm^-1 and spectral resolution of 15 cm^-1. Each vial was measured in triplicates. System check was performance at the start and end of measurements and also each 45 minutes during measurements.

The enclosed dataset includes conventional and surface enhanced Raman spectra (CR and SERS) for cocaine hydrochloride (CAS number 53-21-4), benzoyl ecgonine (CAS number 519-09-5), delta-9-THC (CAS 1972-08-3), Diazepam (CAS 439-14-5)  and paracetamol (CAS 103-90-2) solutions prepared in methanol:water (50:50) and synthetic oral fluid (SAE0149). Spectra of substances’ solutions were acquired using the Agilent Resolve handheld Raman spectrometer equipped with 830 nm laser wavelength.

The enclosed dataset includes attenuated total reflectance-Fourier transform infrared (ATR-FTIR) spectra for cocaine hydrochloride (CAS number 53-21-4), benzoyl ecgonine (CAS number 519-09-5), delta-9-THC (CAS 1972-08-3), Diazepam (CAS 439-14-5) and paracetamol (CAS 103-90-2) solutions prepared in methanol: water (50:50) and synthetic oral fluid (SAE0149).

The enclosed dataset includes conventional and surface enhanced Raman spectra (CR and SERS) for cocaine hydrochloride (CAS number 53-21-4), benzoyl ecgonine (CAS number 519-09-5) and paracetamol (CAS 103-90-2) solutions prepared in methanol:water (50:50) and synthetic oral fluid (SAE0149). Spectra of substances’ solutions were acquired using the Metrohm Mira XTR handheld Raman spectrometer equippespectra d with Orbital Raster Scattering and 785 nm laser wavelength.

The enclosed dataset comprises Raman spectra of cocaine hydrochloride (HCl) and its common adulterants measured using the handheld Agilent Resolve spatially offset Raman spectrometer equipped with 830 nm laser wavelength (Handheld Spectrometer, Portable SORS Raman Technology | Agilent). Adulterant included acetaminophen, baking powder, benzocaine, caffeine, calcium carbonate, custard powder, dextrose, Kendamil milk powder, lactose, lidocaine, levamisole, Nanny milk powder, Nido milk powder, procaine HCl, starch, talc and vanillin.

The enclosed dataset comprises near infrared (NIR) spectra of cocaine hydrochloride (HCl) and its common adulterants using the Viavi microNIR spectrometer equipped with linear variable filter and 128 pixel cooled InGaAS photodiode array detector (MicroNIR 1700EC | VIAVI Solutions Inc.). Adulterant measured were acetaminophen, baking powder, benzocaine, caffeine, calcium carbonate, custard powder, dextrose, Kendamil milk powder, lactose, lidocaine, levamisole, Nanny milk powder, Nido milk powder, procaine HCl, starch, talc and vanillin.

Theis dataset comprises infrared spectral data of 308 street drugs of different formulations, shapes and colours. The details of the street drug samples are enclosed in the ‘ATR-FTIR Scan Log of Samples.xls’ file. ATR-FTIR spectra were collected using the Bruker Alpha-FTIR spectrometer equipped with an ATR diamond holder.

This dataset comprises infrared spectra of six drugs spiked in five different drinks collected using the Agilent 4500a attenuated total reflectance Fourier transform infrared (ATR-FTIR) spectrometer (https://www.agilent.com/en/product/molecular-spectroscopy/ftir-spectroscopy/ftir-compact-portable-systems/4500-series-portable-ftir).

Rapid detection of AKB-48, caffeine and procaine impregnated in paper by handheld Raman spectroscopy.

The attached dataset comprises a handheld Raman spectroscopic dataset of one synthetic cannabinoid derivative and two cutting agents impregnated into paper at four different concentrations and collected using the Rigaku FirstGuard Raman spectrometer equipped with 1064 nm laser wavelength.